Figure 6. Mutations associated with AIS and PCa cluster in the AR-LBD dimer interface.

Cartoon representation of the AR-LBD dimer (yellow) with the side chains of all mutated interface residues shown with all their non-hydrogen atoms as sticks, coloured blue for AIS (a) or red for PCa (b). (c) A complete list of AR missense mutations that affect interface residues reported to date, along with their associated phenotypes. Mutations have been taken from the Androgen Receptor Gene Mutations Database (http://androgendb.mcgill.ca/). For a detailed bioinformatics analysis of the predicted impact of these exchanges see Supplementary Fig. 3, Supplementary Notes and Supplementary Tables 3 and 5.