Table 1. Baseline characteristics of all the enrolled chronic hepatitis C patients.
| Total, n = 669 (treated and untreated) | SVR (+), n = 455 | SVR (−), n = 91 | p-values | |
|---|---|---|---|---|
| Male, n (%) # | 351 (55.6) | 257 (57.8) | 47 (52) | 0.394 |
| Age (yr) | 55.11+/−12.08 | 53.04+/−12.93 | 57.5+/−12.47 | 0.160 |
| BMI | 24.95+/−3.95 | 24.79+/−3.68 | 25.84+/−4.28 | 0.057 |
| HCV RNA (Log10 IU/ml) | 5.97+/−1.12 | 2.95+/−6.26 | 5.68+/−4.96 | <0.001* |
| HCV genotype (G), n (%) # | ||||
| G1 | 368 (55.0) | 214 (47.1) | 72 (79.1) | <0.001* |
| G2 | 263 (39.3) | 214 (47.1) | 17 (18.7) | <0.001* |
| G3 | 15 (2.2) | 12 (2.6) | 0 (0) | 0.386 |
| G6 | 9 (1.3) | 6 (1.3) | 2 (2.2) | 0.335 |
| G1 + G2 | 7 (1.0) | 6 (1.3) | 0 (0) | 0.595 |
| G1 + G3 | 1 (0.1) | 1 (0.2) | 0 (0) | 0.832 |
| Unidentified | 6 (0.9) | 2 (0.8) | 0 (0) | 0.574 |
| HOMA-IR | 3.23+/−5.35 | 3.02+/−6.56 | 5.08+/−8.47 | 0.043* |
| Hepatic steatosis, n (%) # | 311 (46.5) | 218 (48) | 40 (43.75) | 0.373 |
| Liver cirrhosis, n (%) # | 140 (20.9) | 100 (22) | 40 (44.1) | 0.001* |
| ALT (U/L) | 92.09+/−94.59 | 104.7+/−96.0 | 85.6+/−80.0 | 0.116 |
| APRI | 1.64+/−2.04 | 1.479+/−1.92 | 1.758+/−1.986 | 0.21 |
| hsCRP (mg/dL) | 1.68+/−3.71 | 1.70+/−3.16 | 1.59+/−1.97 | 0.752 |
| WBC count (103/μL) | 5.66+/−1.90 | 5.83+/−1.92 | 5.59+/−1.66 | 0.486 |
| Platelets count (103/μL) | 176.9+/−64.5 | 182.2+/−58.5 | 155.6+/−57.7 | 0.001* |
| TC (mg/dL) | 171.3+/−34.5 | 168.05+/−32.08 | 176.29+/−27.90 | 0.735 |
| TGs (mg/dL) | 104.9+/−50.5 | 98.53+/−44.58 | 116.71+/−70.32 | 0.123 |
| PAI-1 (ng/ml) | 6.87+/−3.01 | 6.93+/−3.47 | 6.30+/−4.48 | 0.701 |
| BNP (pg/mL) | 424.2+/−67 | 420.5+/−71.7 | 512.0+/−47.1 | 0.017* |
| Homocysteine (μmol/L) | 14.0+/−7.44 | 14.3+/−7.9 | 13.7+−0.4.5 | 0.76 |
| eGFR | 89.91+/−36.40 | 82.75+/−34.89 | 84.39+/−35.82 | 0.748 |
| PAI-1-rs1799889, 4 G/4 G, n (%) # | 285 (42.6) | 190 (41.7) | 41 (45.1) | 0.984 |
| IFNL3-rs12979860CC, n (%) # | 564 (84.3) | 392 (88.2) | 61 (67) | 0.003* |
#Chi-squared test; SVR: sustained virological response; BMI: body mass index; G: genotype; Log: logarithmic; *p < 0.05; G: genotype; HOMA-IR: homeostasis model assessment-estimated insulin resistance; ALT: alanine aminotransferase; APRI: aspartate aminotransferase to platelet ratio index; hsCRP: high sensitivity C- reactive protein; WBC: white blood cells; TC: total cholesterol; TGs: triglycerides; PAI-1: plasminogen activator inhibitor-1; BNP: brain natriuretic peptide; eGFR: estimated glomerular filtration rate; IFNL3: interferon-λ3.