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. 2017 Feb 13;7:42249. doi: 10.1038/srep42249

Table 4. List of up-regulated and down-regulated pathways in β-thalassemia patients in comparison to healthy controls.

Pathway Name Total Compound Present in Pathway Hits Raw p −log(p) Holm p FDR Impact
Up-regulated:
Fatty acid elongation in mitochondria 27 1 0.0967 2.3362 1 1 0
Glycolysis or Gluconeogenesis 31 1 0.11029 2.2046 1 1 0
Pyruvate metabolism 32 1 0.11366 2.1745 1 1 0.13756
Propanoate metabolism 35 1 0.1237 2.0899 1 1 0
Glycerophospholipid metabolism 39 1 0.13694 1.9882 1 1 0
Galactose metabolism 41 1 0.14348 1.9415 1 1 0.01716
Fatty acid biosynthesis 49 1 0.16924 1.7764 1 1 0
Fatty acid metabolism 50 1 0.17241 1.7579 1 1 0.02959
Starch and sucrose metabolism 50 1 0.17241 1.7579 1 1 0.05947
Down-regulated:
Glycerolipid metabolism 32 1 0.064781 2.7367 1 1 0.18847
Galactose metabolism 41 1 0.082382 2.4964 1 1 0
Fatty acid biosynthesis 49 1 0.097804 2.3248 1 1 0
Glyoxylate and dicarboxylate metabolism 50 1 0.099717 2.3054 1 1 0