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. 2017 Feb 13;7:42114. doi: 10.1038/srep42114

Figure 5. Role of CTGF on macrophage accumulation in anti-GBM nephritis.

Figure 5

(a–c) Immunohistochemical studies for MAC-2 to analyze the number of MAC-2-positive cells per a glomerulus of Rosa-CTGF cKO mice (a), pod-CTGF cKO mice (b) and Pdgfra-CTGF cKO mice (c) at 4 weeks after induction of anti-GBM nephritis. Bar represents 50 μm. (d–f) Expression of Adgre1 (F4/80) mRNA in the glomeruli of Rosa-CTGF cKO mice (d), pod-CTGF cKO mice (e) and Pdgfra-CTGF cKO mice (f) at 4 weeks after induction of anti-GBM nephritis. (g–i) Ccl2 mRNA expression in glomeruli of Rosa-CTGF cKO mice (g), pod-CTGF cKO mice (h) and Pdgfra-CTGF cKO mice (i) at 4 weeks after induction of anti-GBM nephritis. Veh., vehicle; GBM, anti-GBM nephritis; Rosa cKO, Rosa-CTGF cKO mice; pod cKO, pod-CTGF cKO mice; Pdgfra cKO, Pdgfra-CTGF cKO mice. Values were expressed as the means ± s.e. *P < 0.05, **P < 0.01.