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. 2017 Feb 13;7:42114. doi: 10.1038/srep42114

Figure 6. Relevance of CTGF to macrophage phenotypes in anti-GBM nephritis.

Figure 6

(a–c) Expression of Itgax (CD11c, M1 marker) mRNA in the glomeruli of Rosa-CTGF cKO mice (a), pod-CTGF cKO mice (b) and Pdgfra-CTGF cKO mice (c) at 4 weeks after induction of anti-GBM nephritis. (d–f) Mrc1 (CD206, M2 marker) mRNA expression in the glomeruli of Rosa-CTGF cKO mice (d), pod-CTGF cKO mice (e) and Pdgfra-CTGF cKO mice (f). (g–i) Ratio of mRNA expression of M1/M2 macrophage markers in the glomeruli of Rosa-CTGF cKO mice (g), pod-CTGF cKO mice (h) and Pdgfra-CTGF cKO mice (i).Veh, vehicle; GBM, anti-GBM nephritis; Rosa cKO, Rosa-CTGF cKO mice; pod cKO, pod-CTGF cKO mice; Pdgfra cKO, Pdgfra-CTGF cKO mice. Values were expressed as the means ± s.e. *P < 0.05, **P < 0.01.