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. 2017 Feb 13;7:42370. doi: 10.1038/srep42370

Figure 1. Synaptic plasticity impairment in EC slices from 2 month old mhAPP mice.

Figure 1

Field potentials were recorded in EC superficial Layer II after stimulation of the same layer. (A) Input– output curves; the relative amplitude (Rel. Amp.) as a function of stimulus intensity (Stim. Int.) measured in volts (V) did not show significant differences between mhAPP (black diamonds) and WT (open circles). (B) LTP expression was induced by HFS, applied after 15 min of baseline recording. The LTP was induced by HFS stimulation in WT EC slices (open circles), whereas LTP expression was absent in mhAPP slices (black diamonds); insert show representative field potentials recorded either before (a) or 40 min after (b) HFS in WT and mhAPP EC slices (calibration: 1 mV, 5 ms). (C) The LTD expression is not affected in entorhinal cortex slices from 2 month old mhAPP mice as it was reliably inducible by LFS (black diamonds) and comparable to WT (open circles). (D) Field potentials were recorded in hippocampal DG after perforant pathway stimulation; LTP expression in the DG induced by TBS did not differ between WT (open circles) and mhAPP (black circles). Error bars indicate SEM.