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. Author manuscript; available in PMC: 2017 Feb 13.
Published in final edited form as: Nat Rev Neurosci. 2014 Jul;15(7):455–465. doi: 10.1038/nrn3765

Figure 1. Glioma cells associate with blood vessels in the brain.

Figure 1

Most glioma cells that have migrated away from the main tumour mass into the brain parenchyma can be found on blood vessels. Examples of the patient-derived glioma line GBM22 (part a) and of the human glioma cell line D54 (part b) are shown, with high-magnification zooms of the boxed areas on the right. In both examples, glioma cells closely associate with blood vessels in the brain. Human glioma cells are labelled with enhanced green fluorescent protein (EGFP), and murine vessels are labelled with a CD31-specific antibody.