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. 2016 Dec 27;11:708–714. doi: 10.1016/j.redox.2016.12.020

Table 1.

Expression and function of genes encoding ROS-producing or metabolizing enzymes as revealed by studies of loss of function mutants.

Gene Function and cellular/subcellular localization Mutant phenotype
sod-1

  • Superoxide anion to hydrogen peroxide.

  • Ubiquitous/Cytoplasmic [93]
sod-2

  • Superoxide anion to hydrogen peroxide.

  • Mainly expressed in the head and tail regions/Mitochondrial [95]

  • Accelerated wound healing [59]

  • Increased or no effect on

  • lifespan [66], [67], [94], [95]

  • Decreased or no effect in resistance to oxidative stress-inducing agents [66], [67], [94], [95]
sod-3

  • Superoxide anion to hydrogen peroxide

  • Ubiquitous/Mitochondrial

  • [95], [96]

  • Accelerated wound healing [59]

  • Increased or no effect on lifespan [66], [67], [94], [95]

  • Decreased, increased or no effect in resistance to oxidative stress-inducing agents [66], [67], [94], [95]
sod-4

  • Superoxide anion to hydrogen peroxide

  • Nervous system, intestine, somatic gonad/Extracellular and membrane bound [16], [97], [98]

  • Increased or no effect in resistance to oxidative stress-inducing agents [66], [67], [94]
sod-5

  • Superoxide anion to hydrogen peroxide.

  • Amphid neurons/Cytoplasmic [66]

  • No phenotype reported
prdx-2

  • Hydrogen peroxide reduction to water

  • Neurons, intestine and reproductive system/Cytoplasmic [32], [98], [99]

  • Decreased lifespan [32], [100]

  • Increased resistance to arsenite and cadmium but increased sensitivity to hydrogen peroxide [32]

  • Defective feeding response to light [12]

  • Reduced insulin secretion [87]

  • Defect in H2O2-induced potentiation of avoidance behaviour [13]

  • Reduced fecundity and small size [32,99]

  • Impaired PMK-1 activation by arsenite and metformin [32,77]
prdx-3

  • Hydrogen peroxide reduction to water

  • Tissue distribution not determined/Putative mitochondrial

  • Decreased or no effect on lifespan (RNAi) [69], [101]aParaquat sensitive (RNAi) [101]a

  • Reduced fitness (RNAi) [69]a
prdx-6

  • Hydrogen peroxide reduction to water

  • Tissue distribution not determined/Putative cytoplasmic

  • No phenotype reported
ctl-1

  • Hydrogen peroxide reduction to water

  • Tissue distribution not determined/Cytoplasmic [102]

  • Desiccation sensitive [103]
ctl-2

  • Hydrogen peroxide reduction to water

  • Tissue distribution not determined/Peroxisomal [102]

  • Decreased lifespan [68]

  • Reduced egg-laying capacity [68]
ctl-3

  • Hydrogen peroxide reduction to water

  • Pharynx and neurons/Subcellular localization not determined [68]

  • No phenotype reported
bli-3

  • Hydrogen peroxide production and reduction

  • Hypodermis, intestine and pharynx/Subcellular localization not determined [18], [104]

  • Increased pathogen susceptibility [104]

  • Defective collagen cross-linking (RNAi) [18], [20]a

  • Blistered and molting defects [20]
mlt-7

  • Hydrogen peroxide reduction

  • Hypodermis/Subcellular localization not determined [20]

  • Defective collagen cross-linking (RNAi) [20]a

  • Larval arrest (associated to molting defects) and dumpy appearance [20]
skpo-1

  • Hydrogen peroxide reduction

  • Hypodermis/Subcellular localization not determined [21]

  • Increased pathogen susceptibility [21]

  • Decreased lifespan [21]

  • Dumpy [21]
glb-12

  • Superoxide anion production

  • Somatic reproductive system, vulva, head and tail neurons/Plasma membrane [16]

  • Reduced brood size and embryonic lethality [16]

  • Abnormal germline development [16]
a

RNAi phenotypes are provided in those cases that loss of function alleles are not available or have not been tested.