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Reagents and conditions: (a) Et3N, THF, t-BuOH, rt, 5 min.; (b) 55 °C, 62% (2 steps); (c) 23, K3PO4, X-Phos, 2-Me-THF, H2O, Pd2(dba)3, 75 °C, 3 h, 82%; (d) THF, MeOH, NaOH (2 M), 50 °C, 94%; (e) SFC chiral chromatography.
