Table 3. Compound 4 Activity Against Oseltamivir Sensitive and Resistant Influenza A Viruses.
| virus name | type | oseltamivir R/S | 4 CP EC50 (μM)a |
|---|---|---|---|
| A/Georgia/17/2006 | A(H1N1)b | S | 0.009 |
| A/Georgia/20/2006 | A(H1N1)b | R | 0.002 |
| A/Puerto Rico/8/34 | A(H1N1)b | S | 0.014 |
| A/Henan/Jinshui/147/2007 | A(H3N2)b | S | 0.019 |
| A/Texas/12/2007 | A(H3N2)b | R | 0.030 |
| A/California/07/2009 | A(H1N1)c | S | 0.004 |
| A/Texas/48/2009 | A(H1N1)c | R | 0.002 |
| A/Vietnam/1203/2004 | A(H5N1)d | S | 0.004 |
a
Mean MDCK cell 3-day CP (cell protection) assay (MDCK cells incubated with test compounds and influenza A virus for 72 h and the concentration of test compound resulting in 50% cell protection was reported as EC50). N = 3.
b
Seasonal subtype.
c
Pandemic subtype.
d
Highly pathogenic avian influenza (H5N1) strain Oseltamivir R, resistant (determined via externally validated phenotypic or genetic analysis); S, sensitive.