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. 2017 Jan 31;8(2):251–255. doi: 10.1021/acsmedchemlett.6b00479

Table 4. Pharmacokinetic Parameters for Compound 12f Following a Single IV Bolus Dose of 1 mg/kg in Dogs and Monkeys.

Species Dog Monkey
AUC0-INFa 1.45 ± 0.815 0.443 ± 0.094
Unbound AUC0-INFb 10.1 ± 5.7 4.43 ± 0.94
CLc 15.0 ± 6.4 33.5 ± 7.17
Unbound CLc 2140 ± 910 3350 ± 717
T1/2d 1.39 ± 0.21 5.44 ± 0.55
VSSe 1.59 ± 0.58 5.27 ± 3.39
a

μg·h/mL.

b

ng·h/mL.

c

mL/min/kg.

d

hours.

e

L/kg.