. 2017 Jan 11;8(2):168–173. doi: 10.1021/acsmedchemlett.6b00355

Table 1. Antifungal Activities for Phthalazinone and Isoquinolone Analogues Against C. albicans in the Presence of Fluconazole^a.

compd	R¹	R²	EC₅₀ (μM)
1	OMe		0.015 ± 0.002
13	OMe	H	0.033 ± 0.005
14	Me	H	0.065 ± 0.02
15	Br	H	0.003 ± 0.001
16	C≡C(CH₂)₃OH	H	>100
17	Br	Br	0.003 ± 0.001
18	Br	C≡C(CH₂)₃OH	>100
19	Br		>10
20	Br		0.230 ± 0.01
21	Br		0.023 ± 0.008
22	Br		0.020 ± 0.006
23	Br		0.220 ± 0.05
24	Br		0.001 ± 0.0003

Cells incubated with 0.25 μg/mL fluconazole.

Table 1. Antifungal Activities for Phthalazinone and Isoquinolone Analogues Against C. albicans in the Presence of Fluconazolea.