. 2016 Dec 16;8(2):151–156. doi: 10.1021/acsmedchemlett.6b00334

Table 1. IDH1^R132H Biochemical Activity of HTS Hits and Pure Resynthesized Diastereomers.

graphic file with name ml-2016-00334y_0007.jpg

	chirality at amine (Am)	chirality at oxazolidinone (Ox)	biochem. LCMS IC₅₀ (μM)
1a	R/S = 1:1	S	0.8
1b	R/S = 1:1	R	8.5
1c	R	R	19.7
1d	S	R	4.2
1e	R	S	4.6
1f (IDH125)	S	S	0.22

Table 1. IDH1R132H Biochemical Activity of HTS Hits and Pure Resynthesized Diastereomers.