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. 2017 Jan 18;8(2):261–265. doi: 10.1021/acsmedchemlett.6b00487

Table 1. SAR of 2-Position Substituted 7-Azaindole Inhibitors.

graphic file with name ml-2016-00487v_0008.jpg

cmpd R X bDNA EC90a (μM)
6 H H 0.001
12 CH2OH H 0.028
15 CH2OH (R)-F 0.01
16 CH3 H 0.28
17 cyclopropyl H >3.3
19 COOH H 2.2
20 C=NOH H 0.091
21a CH(OH)CH3(R/S) H 0.027
21b CH(OH)CH3(R/S) H 0.46
a

The concentration of test compound resulting in viral RNA levels equal to that of 10% of the control wells was reported as EC90.