Table 4. Rat and Mouse Pharmacokinetic Parameters (PK) for Compounds 6, 12, and 23.

cmpd	6	12	23
rat IV PK (1 mg/kg)
CL (mL/min/kg)	1.2	6.2	7.7
t1/2 (h)	3.2	2.3	1.5
Vss (L/kg)	0.3	0.6	0.4
rat PO PK (3 mg/kg) dose
AUC0-inf (μg·h/mL)	30.3	9.7	1.2
Cmax (μg/mL)	2.6	2.8	0.2
%F	82	100	15.3
mouse PO PK (30 mg/kg)
AUC	336	101	44.5
Cmax (μg/mL)	61.1	37.7	32.1