Table 2.

The effect of zein-based polymeric nanofibers and zein-based polymeric nanofibers loaded with quercetin at various concentrations on foot withdrawal reflex latency (n = 8/group). ^∗∗p < 0.01 and ^∗∗∗p < 0.001, respectively, compared to DM + crush injury and no treatment. ^#p < 0.05 and ^##p < 0.01, respectively, compared to DM + crush injury + zein-based nanofiber.

Paw withdrawal latency (s.)
Group	Baseline	1 day	3 days	6 days	9 days	12 days	15 days	18 days	21 days
DM + crush injury + no treatment	2.40 ± 0.58	3.75 ± 0.56	5.09 ± 0.79	4.06 ± 0.83	2.53 ± 0.39	1.75 ± 0.13	1.93 ± 0.09	1.31 ± 0.07	1.25 ± 0.06
DM + crush injury + zein-based nanofibers	2.12 ± 0.18	3.04 ± 0.30	5.18 ± 0.41	2.31 ± 0.25∗∗	1.78 ± 0.17∗∗	1.62 ± 0.14	1.62 ± 0.11	1.12 ± 0.06	1.12 ± 0.06
DM + crush injury + 5% quercetin	1.87 ± 0.10	2.76 ± 0.23∗∗∗,##	2.40 ± 0.24∗∗,##	1.94 ± 0.19∗∗∗	2.04 ± 0.29∗	1.87 ± 0.15	1.87 ± 0.16	1.06 ± 0.04	1.04 ± 0.04
DM + crush injury + 10% quercetin	1.90 ± 0.14	3.15 ± 0.38∗∗∗	3.34 ± 0.68∗,#	1.59 ± 0.13∗∗∗	1.81 ± 0.14∗∗	1.56 ± 0.10	1.90 ± 0.15	1.03 ± 0.03	1.12 ± 0.06
DM + crush injury + 15% quercetin	1.97 ± 0.00	3.53 ± 0.29∗∗	2.19 ± 0.21∗∗∗,###	2.57 ± 0.22∗	1.96 ± 0.15	1.83 ± 0.25	2.12 ± 0.34	1.53 ± 0.05	1.12 ± 0.06