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Bioluminescence imaging with luciferases and luciferins. (A) Fluc catalyzes the oxidation of D-luciferin. The reaction proceeds through an excited state (S1) oxyluciferin intermediate. Relaxation to the ground state (S0) results in photon release. (B) Crystal structure of a luciferin adenylate bound to Fluc (PDB: 4G36). Targeted positions on the luciferin core are highlighted. (C) Brominated analogs investigated in this study.
