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. Author manuscript; available in PMC: 2018 Feb 7.
Published in final edited form as: Cell Metab. 2017 Jan 5;25(2):448–462. doi: 10.1016/j.cmet.2016.12.008

Figure 2.

Figure 2

Recovery from insulin resistance and glucose intolerance in mice after tamoxifen-treatment. Tamoxifen was administered 5 times over 6 days as indicated by arrows. The day of final injection was considered experimental day 0. (A) Fed glucose levels in Control (n = 17), Ai-IGFRKO (n = 12), Ai-IRKO (n = 12) and Ai-DKO (n = 14) before and after tamoxifen-treatment. (B) HOMA-IR levels at days −3, 3, 13 and 30 of the experiment. (C) Comparison of GTT at day 2 and 30 after tamoxifen-treatment. (D) ITT at day 2 and 30. (E) Liver tissue sections stained with Oil Red O for Control, Ai-IRKO, Ai-IGFRKO and Ai-DKO at day 3 and 30. Scale bars, 100 μm. (F) Liver weights in Control (gray, n = 6), Ai-DKO (red, n = 6) at day 9 and 30. Statistical significance is indicated as p<0.05 (*), p<0.01 (**), p<0.001 (***), and NS = not significant.