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A L-3,4-dihydroxyphenylalanine (DOPA)-containing building block inspired by the human calcitonin (hCT) recognition module. (a) Amino acid sequence of hCT. Underlined are residues 15–19, which constitute the minimal amyloidogenic recognition module of hCT; the chemical structure of the module appears below; (b) the chemical structure of the hCT-inspired DOPA-containing pentapeptide, Asp-DOPA-Asn-Lys-DOPA. The catechol hydroxyl substituents appear in red.
