Figure 9.

(a) Schematic representation of layer-by-layer deposition of vesicle multilayers mediated by noncovalent supramolecular interactions between the cyclodextrin cavities and guest units. The latter provide intervesicular links through the creation of adamantane-biotin-streptavidin or adamantane-mannose-Concavalin A complexes; (b,c) QCM-D data for the immobilization of cyclodextrin vesicles (CDV) via streptavidin-biotin interactions. (b) Fifth resonance frequency overtone of vesicle suspensions with adamantane biotin linker (black curve) and a negative control without a linker (blue curve): top, dissipation data; bottom, frequency data; (c) third to eleventh resonance frequency overtones of a vesicle sample with linker: (top), dissipation data; (bottom), frequency data. The arrows indicate the injection of streptavidin (green), HEPES buffer (blue), vesicles (red), and deionized water (black) [56]. Reprinted with permission from [56]. Copyright 2013, American Chemical Society.