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. 2015 Dec 17;5(4):2317–2334. doi: 10.3390/nano5042317

Figure 2.

Figure 2

Immune responses in mice to pDNA (50 μg per dose) with/without TMC nanoparticles one week after the second booster injection (i.m.). Ag85A-specific serum immunoglobulin G (IgG) titers were analyzed by endpoint enzyme-linked immunosorbent assay (ELISA). (A) Bars represent mean n = 4 ± SEM, * p < 0.05, compared to pDNA alone. (B,C) Corresponding average Log IgG2b/Log IgG1 and Log IgG2c/Log IgG1 ratios are indicative for the quality of the immune response, where values higher than 1 (dotted line) characterize Th1 biased immune responses.