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. 2015 Dec 11;5(4):2231–2248. doi: 10.3390/nano5042231

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Magnetically vectored magnetic nanoparticles (MNPs) accumulate in the brain. (A) A small magnet was implanted in the right hemisphere of the brains of mice by stereotactic injection. (Blue represents the inserted magnet and green shade represents MNPs in cartoon). One week after implantation, MNPs were administered by IV injection. Confocal analysis demonstrated accumulation of the MNPs in the ipsilateral hemisphere, whereas a background level of MNPs was found in the contralateral hemisphere. Scale bar: 500 μm. (B) Confocal analysis of coronal sections of brain demonstrated enrichment of the MNPs near the magnet. Scale bar: 100 μm. Reproduced with permission of [59]. Copyright Elsevier Science, 2012.