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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2016 Dec 21;23(3):420–427. doi: 10.1016/j.bbmt.2016.12.629

Figure 1. Treatment schema for induction of chronic GVHD in DLA-mismatched unrelated HCT recipients.

Figure 1

Recipients were given 920 cGy TBI and donor marrow on day 0. On day 1 recipients were injected with buffy coat cells from a COBE apheresis from their respective donor. Immunosuppression consisted of methotrexate (MTX) administered on days 1, 3, 6, 11 and cyclosporine (CSP) administered on days -1 through 80 at a dose to maintain serum levels between 100 and 300 ng/mL. The average CSP serum level for the 10 dogs on study is shown graphically in the top right portion of the figure. Ursodiol was given on days -1 through 80 to reduce the incidence of liver GVHD.