Table 2. Clinical and histopathological characteristics of chronic GVHD in dogs given 920 cGy TBI followed by unrelated DLA-mismatched HCT*.
| Study | Current (n=8) | Historical (n=10) [29] |
|---|---|---|
| Median days of onset (range) | 91 (29-199) | 124 (59-150) |
| Median days of survival (range) | 98 (38-224) | 150 (69-275) |
| Organ involvement (no. of dogs) | ||
| Skin | 7 | 6 |
| Liver | 6 | 6 |
| Gastrointestinal tract | 6 | 2 |
| Multiple organ involvement (no. of dogs) | ||
| Skin, liver, gut | 4 | 1 |
| Skin, liver | 3 | 1 |
| Skin, gut | 1 | 0 |
| Liver, gut | 0 | 1 |
| Skin only (no. of dogs) | 0 | 4 |
| Liver only | 0 | 3 |
| Gut only | 0 | 0 |
*
Current dogs received a short course of MTX and 80 days of CSP while historical dogs were selected long-term survivors given a 102-day course of MTX [29].