Table 3. Common mouse chronic GVHD models.
| Donor | Recipient | Genetics | Conditioning (TBI in Gy) | Stem Cells | Postgraft Immuno-suppression | Target Organs | Time to GVHD (weeks) | Outcome | Ref |
|---|---|---|---|---|---|---|---|---|---|
| Pro-fibrotic (scleroderma) model | |||||||||
| B10.D2 | BALB/c | H2d (minor) | 7 | marrow+ spleen | none | skin, lungs | 2 to 3 | fibrosis, scleroderma | [42, 43] |
| B10.D2 | BALB/c | H2d (minor) | 6 to 10 | spleen | none | skin | 3 to 7 | scleordema | [44, 45] |
| B10.D2 | BALB/c | H2d (minor) | 8.5 | spleen | none | parotid SG | 3 | sialadenitis | [46] |
|
| |||||||||
| Lupus-like model | |||||||||
| DBA.2 | (B6D2)F1 | H2d/H2b (major) | none | marrow+ spleen | none | NA | 4 to 7 | lymphadenopathy | [47] |
| DBA.2 | (B6D2)F1 | H2d/H2 (major) | none | spleen | none | NA | NA | hyper γ-globulinemia | [48, 49] |
| C57Bl/6 | (B6D2)F1 | H2b/H2bd (major) | none | spleen | none | antibody deposition in kidney | 2 to 4 | anti-ss and ds DNA | [50] |
| BALB/c | (CB6)F1 | H2d/H2bd | none | spleen | none | antibody deposition in kidney | 2 to 4 | autoantibodies | [50] |
|
| |||||||||
| B. obliterans model | |||||||||
| C57Bl/6 | B10.BR | H2b/H2k (major) | Cy+7.5 | marrow (T-depl) spleen | none | lung, colon. liver | 4 to 7 | bronchiolitis. obliterans | [51] |
Abbreviations: salivary gland (SG); total body irradiation (TBI); Gray (Gy); Bronchiolitis (B); cyclophosphamide (Cy); not available (NA).