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. 2017 Feb 7;12:1047–1064. doi: 10.2147/IJN.S115215

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© 2017 Gao et al. This work is published and licensed by Dove Medical Press Limited

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In vivo and ex vivo imaging tests.

Notes: (A) The fluorescent and X-ray pictures of nude mice bearing MCF-7/Adr tumors at various time points after administration with HD micelles/DiR and 7-pep HD micelles/DiR via tail vein. The red arrow points out the tumors in each mouse. (B) Ex vivo fluorescent images and qualitative data of tumors and main organs excised from the mice at 24 h after injection.

Abbreviations: DiR, 1,1-Dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide; h, hour; HD micelles, PHIS-PEG₂₀₀₀ and DSPE-PEG₂₀₀₀ hybrid micelles; DSPE-PEG₂₀₀₀, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000; PHIS-PEG₂₀₀₀, poly(l-histidine)-coupled polyethylene glycol-2000; 7-pep HD micelles, PHIS-PEG₂₀₀₀ and 7pep-DSPE-PEG₂₀₀₀ hybrid micelles; 7pep, HAIYPRH, a TfR ligand.