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. 2017 Feb 7;12:1047–1064. doi: 10.2147/IJN.S115215

Figure 8.

Figure 8

The illustration for the acid-triggered drug release from the pH-sensitive mixed micelles (A) and in vivo tumor targeting and anti-MDR effect mechanisms (B).

Abbreviations: MDR, multidrug resistance; 7pep-DSPE-PEG2000, 7pep-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000; PHIS-PEG2000, poly(l-histidine)-coupled polyethylene glycol-2000; DOX, doxorubicin; EPR, enhanced permeability and retention; 7-pep HD micelles, PHIS-PEG2000 and 7pep-DSPE-PEG2000 hybrid micelles; 7pep, HAIYPRH, a TfR ligand; DSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000.