Table 1.
Effect of CTN on Body Weight in STZ-Treated Diabetic Rats.a
| Day | 0 | 7 | 14 | 21 | 28 |
|---|---|---|---|---|---|
| C | 179.86 ± 7.07 | 219.00 ± 4.85 | 221.40 ± 3.88 | 234.00 ± 5.30 | 252.66 ± 4.59 |
| D | 168.00 ± 5.03 | 162.00 ± 3.63b | 150.33 ± 4.59b | 121.55 ± 3.68b | 102.00 ± 4.96b |
| D + CTN20 | 170.10 ± 4.48 | 172.36 ± 4.79b | 165.12 ± 4.96b | 137.09 ± 5.65b | 143.10 ± 3.91b,c |
| D + CTN40 | 173.50 ± 5.65 | 183.11 ± 4.14b,d | 179.00 ± 3.53b,c | 160.00 ± 3.53b,c,d | 164.00 ± 5.30b,c,e |
| D + CTN60 | 177.02 ± 3.88 | 195.00 ± 3.78c,f,g | 194.72 ± 2.82c,h,i | 181.00 ± 4.59b,c,i,j | 206.09 ± 4.25b,c,i,k |
Abbreviations: CTN, catechin; SEM, standard error of the mean; STZ, streptozotocin.
aControl (C), untreated diabetic rats (D), CTN (20 mg/kg/d)-treated diabetic rats (D + CTN20), CTN (40 mg/kg/d)-treated diabetic rats (D + CTN40), and CTN (80 mg/kg/d)-treated diabetic rats (D + CTN80) during 4 weeks of study. Each measurement was done at least in triplicate, and the values are the means ± SEM for 8 rats in each group.
b P < .001, significantly different from normal control (group C) rats.
c P < .001, significantly different from STZ-treated (group D) rats.
d P < .05, significantly different from STZ-treated (group D) rats.
e P < .05, significant difference between D + CTN20 group versus D + CTN40 and D + CTN80 groups.
f P < .01, significantly different from normal control (group C) rats.
g P < .01, significant difference between D + CTN20 group versus D + CTN40 and D + CTN80 groups.
h P < .05, significantly different from normal control (group C) rats.
i P < .001, significant difference between D + CTN20 group versus D + CTN40 and D + CTN80 groups.
j P < .05, significant difference between D + CTN40 groups versus D + CTN80 group.
k P < .001, significant difference between D + CTN40 groups versus D + CTN80 group.