Table 2. Classification of the placebo–controlled drug trials in neonates in ClinicalTrials.gov (1999–2015) according to design and aim.

Strategy	Total	Curative Treatment	Disease Prevention
	146	89	57
Design	N = 146
Placebo versus drug parallel assignement	105	58	47
Placebo versus drug trial as add-on therapy	36	25	11
Factorial design	3	3	0
Cross-over	2	2	0
Aim	N = 146
Efficacy—Safety	117	64	53
Efficacy with rescue treatment	12	11	1
Pharmacokinetics	17	15	2