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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Trends Cancer. 2016 Sep;2(9):475–484. doi: 10.1016/j.trecan.2016.07.006

Figure 3. Mechanisms of RNA-mediated DNA Rearrangement.

Figure 3

(A) Chimeric RNAs act as repair templates for double strand DNA breakage. Chimeric RNAs pair with one strand of DNA at the double strand breakage site. The repair machinery uses chimeric RNA as the template, and the newly synthesized DNA will share sequence similarity with the chimeric RNA. (B) Chimeric RNAs act as scaffolds to bring two genomic loci into proximity, which might promote the breakage and fusion between the two gene loci. ss-splicing site.