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. 2017 Feb 6;4(1):e1283187. doi: 10.1080/23262133.2017.1283187

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© 2017 Taylor & Francis

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Figure 1. — Modeling WS using human iPSCs: Overview. A model to study the neurodevelopmental aspect of WS subjects. We derived iPSCs from dental pulp cells extracted from deciduous tooth of WS individuals whose neurocognitive and social profile was confirmed. Then, WS patient-derived iPSCs were differentiated into neural progenitor cells (NPCs) and neurons for the investigation of specific cellular phenotypes, such as morphology, electrophysiology, apoptosis, calcium influx and expression profile. Concurrently, we analyzed the morphology of postmortem cortical neurons on same subtype we analyzed in the iPSC-derived neuronal culture. Dashed arrows represent future/possible studies.