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. Author manuscript; available in PMC: 2017 Feb 13.
Published in final edited form as: Curr Opin Toxicol. 2016 Sep 28;1:71–79. doi: 10.1016/j.cotox.2016.09.001

Figure 1. Regulatory effects of NRF2 network variation.

Figure 1

(A) General schematic of NRF2 regulatory pathway. See text for details. (B) Mutations that disrupt NRF2-KEAP1 interactions lead to NRF2 hyperactivation and are associated with tumorigenesis. Select NRF2 target genes are consistently upregulated in tumors with hyperactivated NRF2. (C) Variants that disrupt individual ARE sequences create alleles with stronger ARE activity and weaker ARE activity. Such variants can alter NRF2 target gene expression and, in some cases, disease risk.