Table 1. Genes consistently upregulated in tumors with hyperactivated NRF2.
Bold genes are direct NRF2 targets based on human ChIP-seq data [13,14]. Non-bold genes are direct NRF2 targets based on additional experimental evidence [48]. “Additional genes” are those with little evidence for direct regulation by NRF2. Tumor expression data are from [43].
| Gene symbol | Gene name | Tumor type |
|---|---|---|
| Upregulated in 4/4 NRF2 hyperactivated tumor types: | ||
| ABCB6 | ATP binding cassette subfamily B member 6 | B, H, L, U |
| ALDH3A1 | Aldehyde dehydrogenase 3 family member A1 | B, H, L, U |
| FECH | Ferrochelatase | B, H, L, U |
| GCLM | Glutamate-cysteine ligase, modifier subunit | B, H, L, U |
| ME1 | Malic enzyme 1 | B, H, L, U |
| NQO1 | NAD(P)H quinone dehydrogenase 1 | B, H, L, U |
| PGD | Phosphogluconate dehydrogenase | B, H, L, U |
| SRXN1 | Sulfiredoxin 1 | B, H, L, U |
| TALDO1 | Transaldolase 1 | B, H, L, U |
| TKT | Transketolase | B, H, L, U |
| TXNRD1 | Thioredoxin reductase 1 | B, H, L, U |
| OSGIN1 | Oxidative stress induced growth inhibitor 1 | B, H, L, U |
| AKR1C1 | Aldo-keto reductase family 1 member C1 | B, H, L, U |
| EPHX1 | Epoxide hydrolase 1 | B, H, L, U |
| G6PD | Glucose-6-phosphate dehydrogenase | B, H, L, U |
| Additional genes: AKR1B10, AKR1C2, AKR1C3, CABYR, CES1, CYP4F3, JAKMIP3, PANX2, TRIM16L | ||
| Upregulated in 3/4 NRF2 hyperactivated tumor types: | ||
| GCLC | Glutamate-cysteine ligase catalytic subunit | B, H, U |
| GSR | Glutathione reductase | B, H, L |
| PRDX1 | Peroxiredoxin 1 | B, H, L |
| SLC7A11 | Solute carrier family 7 member 11 | B, H, L |
| TXN | Thioredoxin | B, H, L |
| PTGR1 | Prostaglandin reductase 1 | B, H, L |
| Additional genes: AGPAT9, CBR3, CES4, CLDN8, CYP4F11, FTHL3, KIAA0319, MAP2, MDGA1, NAMPT, RBM19, RIT1, SAMD5, SPP1, TDP2, TSPAN7, WNT5A | ||
| Upregulated in 2/4 NRF2 hyperactivated tumor types: | ||
| ABHD4 | Abhydrolase domain containing 4 | H, L |
| ADAM17 | ADAM metallopeptidase domain 17 | B, L |
| COA6 | Cytochrome c oxidase assembly factor 6 | B, L |
| FTH1 | Ferritin heavy chain 1 | H, U |
| KEAP1 | Kelch like ECH associated protein 1 | B, L |
| MAF-G | MAF bZIP transcription factor G | B, L |
| PIR | Pirin | B, U |
| SLC12A8 | Solute carrier family 12 member 8 | H, L |
| SLC3A2 | Solute carrier family 3 member 2 | B, L |
| TLK1 | Tousled like kinase 1 | H, L |
| TMTC3 | Transmembrane and tetratricopeptide repeat containing 3 | B, L |
| ZNF746 | Zinc finger protein 746 | B, L |
| ABCC1 | ATP binding cassette subfamily C member 1 | B, H |
| ABCC3 | ATP binding cassette subfamily C member 3 | H, L |
| ADH7 | Alcohol dehydrogenase 7 | B, L |
| CBR1 | Carbonyl reductase 1 | B, H |
| GPX2 | Glutathione peroxidase 2 | H, L |
| IDH1 | Isocitrate dehydrogenase 1 | H, L |
| PRDX6 | Peroxiredoxin 6 | H, L |
| Additional genes: ABCA4, ADAM23, AKR1B15, ANXA10, ASF1A, ASPH, C14orf149, CREG1, DNAJB4, EPS8, EPT1, ETFB, FAM190A, FBXO30, GLI2, GSTM3, GSTM4, HHIPL2, LOC729082, MAP1B, MEGF9, NECAB2, NSUN3, PHEX, PHKB, RAP1GAP, RNF217, SLC47A2, SLC9A3R1, SMOC2, SOST, TNPO1, TPD52L1, TRIM16, TSKU, UGT1A7 | ||
Tumor type abbreviations: B = Bladder Urothelial Carcinoma; H = Head–Neck Squamous Cell Carcinoma; L = Lung Squamous Cell Carcinoma; U = Uterine Corpus Endometrial Carcinoma.