Table 3. The AUC and AUPR values of the five methods for the four types of proteins in each validation set (previous and updated dataset).

		Enzymes		Ion channels		GPCRs		Nuclear receptors
		Previous	Updated	Previous	Updated	Previous	Updated	Previous	Updated
SELF-BLM	AUC	0.974	0.859	0.977	0.941	0.952	0.914	0.890	0.799
BLM		0.968	0.846	0.972	0.923	0.94	0.893	0.869	0.767
BLM-RBF		0.974	0.880	0.975	0.903	0.930	0.880	0.909	0.792
LapRLS		0.954	0.883	0.960	0.915	0.894	0.872	0.816	0.778
NetLapRLS		0.960	0.869	0.958	0.928	0.926	0.917	0.867	0.789
SELF-BLM	AUPR	0.846	0.637	0.805	0.762	0.566	0.614	0.625	0.573
BLM		0.862	0.629	0.842	0.745	0.676	0.610	0.599	0.534
BLM-RBF		0.891	0.652	0.922	0.758	0.709	0.590	0.609	0.514
LapRLS		0.704	0.538	0.744	0.658	0.400	0.401	0.387	0.452
NetLapRLS		0.806	0.609	0.827	0.735	0.637	0.596	0.456	0.458