Figure 9. Proposed models for autoregulation imposed by the NTR and the recognition process of the H4 tail.
The ppHSA motif, AcidicN and AutoN dock against Lobe 2 of the ATPase domain, promoting an overall structural architecture of the ATPase module that is reminiscent of Chd1 (Figure 4A). AcidicN and AutoN functionally collaborate in the H4 tail recogniton process. The docking site of AutoN-AcidicN is adjacent to the H4 tail potentially allowing simultaneous binding (top). Alternatively, the H4 tail may displace the NTR as suggested previously (bottom) (Clapier and Cairns, 2012).