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. Author manuscript; available in PMC: 2018 Feb 10.
Published in final edited form as: Annu Rev Physiol. 2016 Nov 14;79:237–260. doi: 10.1146/annurev-physiol-022516-034102

Figure 3.

Figure 3

Localization of some of the signaling proteins that regulate meiotic arrest and resumption in preovulatory follicles. Protein distribution is either determined directly, by ligand binding, immunofluorescence, or Western blotting; or it is inferred from mRNA distribution, by in situ hybridization, or from RT-qPCR. Green indicates the presence of the protein, and lighter green indicates a lesser amount of the protein. White indicates that the protein (or mRNA) was either not detected or detected at a level ≤10% of that elsewhere. Figure is based on data from the following references: CNP precursor (66); connexin 43 (9), connexin 37 (9), EGF receptor (99; LA Jaffe and JR Egbert, unpublished data); epiregulin and amphiregulin precursors (99); GPR3/12 (40, 46); LH from blood vessels (14); LH receptor (84); NPR2 (66, 70); and PDE3A (61, which used a previous nomenclature, PDE3B). Abbreviations: CNP, C-type natriuretic peptide; EGF, epidermal growth factor; LH, luteinizing hormone; NPR2, natriuretic peptide receptor 2; PDE3A, phosphodiesterase 3A.