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. Author manuscript; available in PMC: 2018 Feb 10.
Published in final edited form as: Annu Rev Physiol. 2016 Nov 14;79:237–260. doi: 10.1146/annurev-physiol-022516-034102

Figure 4.

Figure 4

LH-induced cGMP decreases in a mouse ovarian follicle from a transgenic mouse expressing the cGMP FRET sensor cGi500. A larger CFP/YFP emission ratio indicates higher cGMP. Ratios are color-coded: Yellow indicates high cGMP, and turquoise indicates low cGMP. Before LH perfusion, cGMP is high throughout the follicle but low in the theca cells. At 5 min after LH perfusion, cGMP has decreased in the mural cells but not in the cumulus cells or oocyte. At 20 min, cGMP has decreased throughout the follicle. Figure modified from Reference 71. Abbreviations: CFP, cyan fluorescent protein; cGMP, cyclic GMP; FRET, Förster resonance energy transfer; LH, Luteinizing hormone; YFP, yellow fluorescent protein.