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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Curr Opin Biotechnol. 2016 Aug 20;43:17–24. doi: 10.1016/j.copbio.2016.07.006

Figure 4.

Figure 4

(a) Schematic representation of the SUMMIT MS/NMR approach for the rapid and accurate identification of unknown metabolites in complex mixtures. Adapted with permission from [35]. Copyright 2015 American Chemical Society. (b) Nanoparticle-assisted NMR metabolomics approach for the selective suppression of the NMR signals of metabolites based on their charge and hydrophobicity. When metabolites interact (even only transiently) with the surface of charged silica nanoparticles they undergo rapid transverse relaxation, which results in substantial line broadening or complete peak disappearance in the NMR spectrum.[40]