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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Eur J Neurosci. 2016 Nov 12;45(4):490–498. doi: 10.1111/ejn.13446

Figure 4.

Figure 4

Cotinine effects on performance of Fmr1−/− mice in four cognitive tasks.

(A) Performance of wild-type (WT) mice (n=15) and Fmr1−/− mice (n=14) in the coordinate spatial processing task (Means±SEM; *p<0.05 compared to vehicle-treated WT mice). (B) Performance of WT mice (n=16) and Fmr1−/− mice (n=15) in the categorical spatial processing task (Means±SEM; *p<0.05 compared to vehicle-treated WT mice). (C,D) Performance of wild-type (WT) mice (n=16), and Fmr1−/− mice (n=15) on novel object recognition. (C) Percent time spent exploring the novel (N) and familiar (F) object. (Means±SEM; *p<0.05 compared to time spent with familiar object). (D) Discrimination index (Means±SEM; *p<0.05 compared to vehicle-treated WT mice). (E,F) Performance of WT mice (n=16) and Fmr1−/− mice (n=15) on the temporal order task. (E) Percent time spent exploring the first (1) and last (3) object presented. (Means±SEM; *p<0.05 compared to time spent with object 1). (F) Discrimination index (Means±SEM; *p<0.05 compared to vehicle-treated WT mice).