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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Eur J Neurosci. 2016 Nov 12;45(4):490–498. doi: 10.1111/ejn.13446

Figure 5.

Figure 5

Cotinine effects on performance of GSK3β KI mice in two cognitive tasks.

A) Immunoblots from 3 mice in each group showing the absence of serine-9 phosphorylation of GSK3β in the hippocampus of male GSK3β KI mice. Total levels of GSK3β are equal in GSK3β KI and wild-type (WT) mice. (B) Performance of wild-type (WT) mice (n=15) and GSK3β KI (GSK3β KI) mice (n=18) in the coordinate spatial processing task (Means±SEM; *p<0.05 compared to vehicle-treated WT mice). (C,D) Performance of WT mice (n=16) and GSK3β KI mice (n=19) on novel object recognition. (C) Percent time spent exploring the novel (N) and familiar (F) object. (Means±SEM; *p<0.05 compared to time spent with familiar object). (D) Discrimination index (one-way ANOVA, F(3,34)=5.38, p<0.01; Means±SEM; *p<0.05 compared to vehicle-treated WT mice).