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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Aug 13;110-111:157–168. doi: 10.1016/j.addr.2016.08.004

Fig. 1. CPP-mediated siRNA intracellular delivery.

Fig. 1

A). Schematic illustration of formulation schemes for CPP-mediated siRNA cell entry. (1) CPP-siRNA conjugate; (2) CPP-siRNA nanocomplex; (3) siRNA anchored on an antibody-CPP conjugate; (4) hairpin-structured activatable CPP conjugated with siRNA. B) The helical wheel showing the amphiphilicity of α-helical CPPs: Penetratin, CADY, and KALA. Amino acids are color coded (red: charged; orange: apolar; yellow: polar; gray: hydrophobic).