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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Aug 13;110-111:157–168. doi: 10.1016/j.addr.2016.08.004

Fig. 3.

Fig. 3

Gene and siRNA delivery by multifunctional peptides. A) Schematic of the trifunctional peptide for targeted gene delivery. The KALA domain promotes endosome escape; the tandem H1 repeats enable DNA condensation; the NLS sequence enhances nucleus translocation; and the TP1 block serves as a ligand for cell-specific homing. B) Sequence-specific RNA binding peptide U1A-RBD-Tat forms a complex with U1A modified siRNA, which can escape endosome aided by photo-induced endosomolysis. AF546: Alexa Fluor 546. C) Schematic drawing of a siRNA associated with PTD modified dsRBD. Adapted with permission from ref. [139]. Copyright 2009 Nature Publishing Group. D) dsRBD-His18 chimeric peptide as a general platform for targeted delivery of aptamer-siRNA chimeras. Orange: PSAM targeting aptamer; green: siRNA.