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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Aug 13;110-111:157–168. doi: 10.1016/j.addr.2016.08.004

Table 2.

Endosome disrupting peptides for siRNA delivery.

Peptide Mechanism of action Sequence Ref.
HA2 Conformation changing GLFGAIAGFIENGWEGMIDGWYG [39, 86, 87]
INF7 Conformation changing GLFEAIEGFIENGWEGMIWDYG [88]
E5 Conformation changing GLFEAIAEFIEGGWEGLIEG [92]
E5WYG Conformation changing GLFEAIAEFIEGGWEGLIEGWYG [92]
C6M1 Conformation changing Ac-RLWRLLWRLWRRLWRLLR-amide [93]
GALA Conformation changing WEAALAEALAEALAEHLAEALAEALEALAA [96-100]
EB1 Conformation changing LIRLWSHLIHIWFQNRRLKWKKK-amide [39]
H5WYG Conformation changing GLFHAIAHFIHGGWHGLIHGWYG [105, 106]
Endoporter Conformation changing LHKLLHHLLHHLHKLLHHLHHLLHKL [40, 102, 107]
Melittin Chemical structure changing GIGAVLKVLTTGLPALISWIKRKRQQ-amide (CDM modified) [109]
H3K8b Proton buffering K3(HHHHNHHHH(HHHKHHHKHHHKHHH)2)4 [115, 116]
PepFect 6 Proton buffering Stearyl-AGYLLGK(K3QN4)INLKALAALAKKIL-amide [118]
TatU1A-Alexa Photo induced endosomolysis RKKRRQRRR-U1A-Alexa Fluor 546 [125]