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. Author manuscript; available in PMC: 2017 Jun 21.
Published in final edited form as: Acc Chem Res. 2016 Jun 8;49(6):1242–1249. doi: 10.1021/acs.accounts.6b00151

Figure 4.

Figure 4

Multiple folds of the B. subtilis trp 5’UTR RNA lead to activation of PKR. A 206 nt transcript with multiple features including a 5’-stem loop, long dsRNA region, and a terminator hairpin. This RNA binds the protein TRAP, which is activated by excess L-trp, and leads to the translation control structure shown at the right, where the Shine-Dalgarno sequence is blocked. In addition, the naked RNA has a magnesium-dependent tertiary (pseudoknot) feature shown in blue and pink in the lower panel. (Adapted with permission from ref. 55. Copyright 2015 Elsevier.)