Table 2.
Univariate and multivariate Cox proportional analysis for overall survival
| Parameter | Categoriesa | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95 % CI) | P b | HR (95 % CI) | P c | ||
| Age | <65/≥65 years | 1.45 (1.07–1.96) | 0.016 | 1.74 (1.19–2.55) | 0.004 |
| Gender | Female/male | 1.07 (0.80–1.43) | 0.662 | – | |
| NLR | <5, ≥5 | 1.58 (1.12–2.72) | 0.001 | 1.66 (1.12–2.46) | 0.012 |
| LMR | ≥3, <3 | 1.93 (1.19–3.11) | 0.001 | 1.65 (1.06–2.58) | 0.026 |
| CA 19-9 level | <180/> 180 U/mL | 1.04 (0.68–1.41) | 0.623 | – | |
| Tumor location | Head/other | 1.09 (0.77–1.54) | 0.599 | – | |
| Tumor size | <20/≥20 mm | 1.08 (0.74–1.58) | 0.675 | – | |
| Perineural invasion | No/yes | 1.41 (1.06–1.89) | 0.018 | 1.32 (0.75–2.31) | 0.332 |
| Lymphovascular invasion | No/yes | 0.98 (0.59–1.60) | 0.935 | – | |
| Tumor differentiation | Well/other | 1.36 (0.81–2.28) | 0.237 | – | |
| AJCC T category | T1–2/T3–T4 | 2.25 (1.23–4.09) | 0.008 | 2.90 (0.73–11.42) | 0.127 |
| AJCC N category | N0/N1 | 1.57 (1.13–2.17) | 0.007 | 1.75 (1.090–2.79) | 0.019 |
| Metastatic lymph node ratio | <0.2; ≥0.2 | 1.92 (1.39–2.65) | <0.001 | 1.69 (1.10–2.60) | 0.016 |
| AJCC stage | I/II and III | 1.86 (1.01–3.45) | 0.049 | 2.96 (0.79–13.94) | 0.337 |
| Resection margin | R0/R1 and 2 | 2.17 (1.51–3.11) | <0.001 | 2.16 (1.16–4.02) | 0.015 |
| Chemotherapy | Yes/no | 0.94 (0.61–1.45) | 0.794 | – | |
CI confidence interval, HR hazard ratio, NLR neutrophil-lymphocyte ratio, LMR lymphocyte-monocyte ratio
aReference category listed first
bLog Rank Mantel–Cox test
cCox proportional hazards model