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. 2017 Jan 10;79(2):353–361. doi: 10.1007/s00280-016-3218-0

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Observed versus simulated pertuzumab serum concentrations by treatment group. The dashed lines represent 97.5th and 2.5th percentiles based on simulations by the population PK model and the observed lean body weight and albumin distributions in NeoSphere. The solid lines are the population PK model predictions for a patient with the median values of lean body weight and albumin for each treatment group. The open circles represent C _trough serum concentrations observed for NeoSphere patients