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. 2017 Jan 10;79(2):353–361. doi: 10.1007/s00280-016-3218-0

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — pCR response rate versus pertuzumab predicted C _trough serum concentrations (in combination with trastuzumab and docetaxel). Square symbols represent percent pCR (pathological complete response) of the patients grouped by pertuzumab serum concentration into third tiles (separated by vertical dashed lines). The group with zero pertuzumab serum concentration refers only to all patients in Arm A. Error bars represent 2 × standard error [2 × √(p×(1 − p)/n)]. The open circles represent the response status of individual patients (0% = non-responder, 100% = responder)