Fig. 3.

Use of PICD for patients. At the patient level, individualized PBPK models are developed by incorporating anthropometric parameters of patients (e.g., weight). PICD is then individually applied on each patient-specific PBPK model by taking into account the respective dosage regimen (administration route and dose level). Concentration–time profiles are therefore simulated in the interstitial space of the liver and correspondent in vivo drug response profiles are predicted at the cellular level following administration of the specific dose