Table 2.

Experimental conditions

Administration route	Dose (mg)	Subjects	Usage	References
Intravenous bolus	50	Healthy (n = 24)	Reference	(Van Os et al. 1996)
Intravenous bolus	100	Uremic patient (n = 1)	Validation	(Odlind et al. 1986)
Oral	100	Healthy (n = 10)	Validation	(Zins et al. 1997)

Administration route, respective doses, health state and number of subjects. The experimental PK data were either used for establishment of the reference PBPK model (references) or for model validation (validation)