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. 2017 Feb 14;8:14. doi: 10.3389/fgene.2017.00014

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Copyright © 2017 Iñiguez and Hernández.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evolutionary models of AS after GD. The three different proposed models of evolution of AS after GD are depicted. Color boxes represent exons while black lines represent introns from a gene. The upper part represents a single-copy gene, before GD, that give rise to the different mRNA isoforms (connected by a dash-line arrow) due to AS. The lower part represents the same gene after GD and each of the possible evolutionary models of AS. The isoforms highlighted in a dashed line box represent those present before GD.